The 36-year-old defender, who excelled in his only competitive start of the season against Bodo/Glimt last week, could be favored by head coach Cristian Chivu as Inter desperately seeks to overturn a 3-1 first-leg deficit to reach the Round of 16.
Luis Henrique, who started in Saturday's Serie A match at Lecce, may drop to the bench for this 'make or break' European showdown as Darmian's experience becomes crucial for the Italian side's hopes.